Dr. Mudd is most infamously known for his involvement in the assassination of President Abraham Lincoln, who was shot by John Wilkes Booth in 1865. Mudd’s first encounter with Booth was less than a year before the assassination, during a discussion regarding the sale of a horse. A month later, Mudd, Booth, John Surratt and Louis Weichman shared drinks in a hotel room rented by Booth. During his assassination of the president, John Wilkes Booth broke his leg and sought the help of Dr. Mudd and stayed at Mudd’s residence until the next day.
Mudd was later arrested for conspiracy and for harboring Booth and David Harold after the crime was committed. After standing trial and a string of testimonies, Dr. Samuel Alexander Mudd was convicted and sentenced to life imprisonment at Fort Jefferson in the Dry Tortugas.